(S)-2,2'-Bis[bis(4-methoxy-3,5-dimethylphenyl)phosphino]-4,4',6,6'-tetramethoxy)-1,1'-biphenyl
(S)-2,2'-Bis[bis(4-methoxy-3,5-dimethylphenyl)phosphino]-4,4',6,6'-tetramethoxy)-1,1'-biphenyl
CAS: 1365531-94-7
Molecular Formula: C52H60O8P2
(S)-2,2'-Bis[bis(4-methoxy-3,5-dimethylphenyl)phosphino]-4,4',6,6'-tetramethoxy)-1,1'-biphenyl - Names and Identifiers
| Name | (S)-2,2'-Bis[bis(4-methoxy-3,5-dimethylphenyl)phosphino]-4,4',6,6'-tetramethoxy)-1,1'-biphenyl |
| Synonyms | (S)-2,2'-Bis[bis(4-Methoxy-3,5-diMethylphenyl)phosphino]-4,4',6,6'-tetraMethoxybiphenyl (S)-2,2'-Bis[bis(4-methoxy-3,5-dimethylphenyl)phosphino]-4,4',6,6'-tetramethoxy)-1,1'-biphenyl (S)-2,2'-Bis[bis(4-Methoxy-3,5-diMethylphenyl)phosphino]-4,4',6,6'-tetraMethoxybiphenyl (S)-DMM-Garphos Phosphine, 1,1'-[(1S)-4,4',6,6'-tetramethoxy[1,1'-biphenyl]-2,2'-diyl]bis[1,1-bis(4-methoxy-3,5-dimethylphenyl)- |
| CAS | 1365531-94-7 |
(S)-2,2'-Bis[bis(4-methoxy-3,5-dimethylphenyl)phosphino]-4,4',6,6'-tetramethoxy)-1,1'-biphenyl - Physico-chemical Properties
| Molecular Formula | C52H60O8P2 |
| Molar Mass | 874.98 |
| Boling Point | 865.4±65.0 °C(Predicted) |
| Appearance | crystal |
| Color | white |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Sensitive | Air Sensitive |
(S)-2,2'-Bis[bis(4-methoxy-3,5-dimethylphenyl)phosphino]-4,4',6,6'-tetramethoxy)-1,1'-biphenyl - Introduction
(S)-2,2 '-Bis[bis(4-methoxy-3,5-dimethylphenyl)phosphino]-4,4',6,6 '-tetramethoxy)-1,1'-biphenyl, also known as (S)-BINAP, is an organophosphorus ligand. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance:(S)-BINAP is a white to pale yellow crystal.
-Solubility: It is soluble in most organic solvents, such as dimethylformamide, acetonitrile, dichloromethane, etc.
Use:
(S)-BINAP is widely used as a ligand in metal catalysis and asymmetric synthesis:
-Metal catalysis: It can form complexes with transition metals and play an important role in a variety of catalytic reactions, such as asymmetric hydrogenation, asymmetric ethylene glycol synthesis, asymmetric carbonylation and so on.
-Asymmetric synthesis: As a chiral ligand,(S)-BINAP can be used to synthesize chiral organic compounds, such as chiral drugs and fine chemicals.
Preparation Method:
(S)-BINAP can be synthesized by the following steps:
1. First, the phosphorylation reaction is carried out on the basis of 4-methoxy -3,5-dimethylphenol to introduce the phosphate group into the benzene ring.
2. Subsequently, a substitution reaction was performed to substitute the two phosphate groups with 4-methoxy-3, 5-dimethylphenyl groups.
3. Finally, the two benzene rings were connected by aromatic carbonylation to obtain the target product (S)-BINAP.
Safety Information:
There is limited safety data on (S)-BINAP, but in general, it is considered a relatively safe compound. However, like other organophosphorus compounds, it may be toxic and irritating to the human body. When handling and handling (S)-BINAP, follow the necessary laboratory safety procedures and wear personal protective equipment.
Nature:
-Appearance:(S)-BINAP is a white to pale yellow crystal.
-Solubility: It is soluble in most organic solvents, such as dimethylformamide, acetonitrile, dichloromethane, etc.
Use:
(S)-BINAP is widely used as a ligand in metal catalysis and asymmetric synthesis:
-Metal catalysis: It can form complexes with transition metals and play an important role in a variety of catalytic reactions, such as asymmetric hydrogenation, asymmetric ethylene glycol synthesis, asymmetric carbonylation and so on.
-Asymmetric synthesis: As a chiral ligand,(S)-BINAP can be used to synthesize chiral organic compounds, such as chiral drugs and fine chemicals.
Preparation Method:
(S)-BINAP can be synthesized by the following steps:
1. First, the phosphorylation reaction is carried out on the basis of 4-methoxy -3,5-dimethylphenol to introduce the phosphate group into the benzene ring.
2. Subsequently, a substitution reaction was performed to substitute the two phosphate groups with 4-methoxy-3, 5-dimethylphenyl groups.
3. Finally, the two benzene rings were connected by aromatic carbonylation to obtain the target product (S)-BINAP.
Safety Information:
There is limited safety data on (S)-BINAP, but in general, it is considered a relatively safe compound. However, like other organophosphorus compounds, it may be toxic and irritating to the human body. When handling and handling (S)-BINAP, follow the necessary laboratory safety procedures and wear personal protective equipment.
Last Update：2024-04-09 21:01:54
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Product Name: (S)-2,2'-Bis[bis(4-Methoxy-3,5-diMethylphenyl)phosphino]-4,4',6,6'-tetraMethoxybiphenyl, 97+% Visit Supplier Webpage Request for quotation
CAS: 1365531-94-7
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CAS: 1365531-94-7
Tel: 18301782025
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Mobile: 18021002903
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